Immunotoxins directed by monoclonal antibody to .ALPHA.-fetoprotein.
نویسندگان
چکیده
منابع مشابه
MONOCLONAL ANTIBODIES TO HUMAN ALPHA-FETOPROTEIN
Alpha-fetoprotein (AFP), a serum glycoprotein belonging to the onco-developmental proteins group, serves as a marker both in cancer research and in studies concerning fetal development and fetal pathophysiology. Monoclonal anti-AFP antibodies are essential reagents in developing appropriate techniques for measurement of this protein. In this study, in order to produce anti-AFP monoclonal a...
متن کاملmonoclonal antibodies to human alpha-fetoprotein
alpha-fetoprotein (afp), a serum glycoprotein belonging to the onco-developmental proteins group, serves as a marker both in cancer research and in studies concerning fetal development and fetal pathophysiology. monoclonal anti-afp antibodies are essential reagents in developing appropriate techniques for measurement of this protein. in this study, in order to produce anti-afp monoclonal antibo...
متن کاملDiagnosis of premature rupture of membranes with an improved alpha-fetoprotein monoclonal antibody kit.
We developed a new kit for detecting alpha-fetoprotein (AFP) in leaked amniotic fluid (Eur J Obstet Gynecol Reprod Biol 1995;58:67-72). Later, we developed an improved AFP kit utilizing the same AFP monoclonal antibody. We compared this improved AFP test with the nitrazine test for 137 patients. The nitrazine test correctly diagnosed 62.1% of the cases, but the improved AFP kit diagnosed 98.0% ...
متن کاملLocalization of radioiodinated antibody to alpha-fetoprotein in hepatoma transplanted in rats and a case report of alpha-fetoprotein antibody treatment of a hepatoma patient.
The localization of radioactive iodine-labeled anti-a-fetoprotein (AFP) antibody in transplanted rat hepatomas was exam ined by total body scintigraphy, subcellular distribution of ra dioactivity, and microautoradiography of tissues. The specific antibody was isolated from anti-rat AFP horse antiserum by immunoadsorbent that was coupled with rat AFP and radioiodinated with 125I.F(ab')? was isol...
متن کاملA monoclonal antibody to alpha-human atrial natriuretic polypeptide.
A monoclonal antibody to alpha-human atrial natriuretic polypeptide (alpha-hANP), KY-ANP-I, has been produced by fusion of a nonproducing mouse myeloma cell line, X63-Ag8.653, with spleen cells from BALB/c mice immunized with synthetic alpha-hANP conjugated to bovine thyroglobulin using the carbodiimide coupling procedure. Hybridomas were screened for antibody production by radioimmunoassay usi...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 1994
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.9.13